In simple ectopia lentis, the lens dislocation is usually bilateral and occurs most often in the superotemporal direction. mutations to the FBN1 gene can also result in Marfan syndrome). Significant overlap exists between the genetics of simple ectopia lentis and the systemic diseases associated with ectopia lentis (e.g. These mutations often result in irregularity and degeneration of the zonular fibers, leading to lens dislocation. Mutations resulting in simple ectopia lentis include mutations to the ADAMTSL4 gene located on chromosome 1 (recessive inheritance pattern) and the FBN1 gene located on chromosome 15 (dominant inheritance pattern). Both are hereditary and can be inherited in an autosomal dominant or recessive pattern. Simple ectopia lentis – simple ectopia lentis can occur as a congenital disorder or as a spontaneous disorder later in life. Ocular diseases associated with ectopia lentis Though trauma is the most common cause of ectopia lentis, if the trauma is minor, one should consider other underlying diseases that could predispose the patient to lens dislocation. Traumatic ectopia lentis is most often the result of a direct blow to the eye, such as from a baseball or golf ball, but can also occur after blunt trauma to the head or orbit. It may be present at birth or occur at any age. The lens is being seen through dilated pupil in down gaze.Įctopia lentis can occur due to trauma, ocular disease, or systemic disease. Traumatic dislocation of crystalline lens into vitreous cavity.
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